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hematology abnormal algorithm bruising intravascular anemia bleeding disorders extravascular hemolysis hemolytic hemorrhage hemostasis inr management obgyn obstetrics pediatrics peds postpartum
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... PT and aPTT 1. ... coagulation (DIC ... #aPTT #Prolonged ... #Causes #diagnosis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... PTT, Normal PT ... Differential #Diagnosis ... #Hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and aPTT If ... aPTT are both prolonged ... #aPTT #Prolonged ... #Causes #diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Coagulation (DIC ... Thrombocytopenia • Prolonged ... PT/PTT • Low ... INR < 2.3 - APTT ... #diagnosis #causes
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Diagnosis Algorithm ... . prolonged/induced ... HELLP syndrome • Disseminated ... (DIC) • Anti-coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... prolonged after ... failure, disseminated ... discern these causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): - Disseminated ... intravascular coagulation ... (DIC) - HELLP ... #differential #
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
purpura - DIC ... (disseminated intravascular ... coagulation) ... peds #pediatrics #diagnosis ... #differential #
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