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diagnosis hematology abnormal bruising intravascular pt algorithm anemia bleeding dermatology disseminated extravascular hemolysis hemorrhage hemostasis management nonpalpable obgyn obstetrics palpable
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... (DIC) c. ... #Prolonged #Causes ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... thrombocytopenic purpura ... #differential #
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... Petechiae • Purpura ... Treat primary cause ... INR < 2.3 - APTT ... #diagnosis #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... /TTP/HUS - Hemolytic ... Defects: • DIC ... Fulminans (DIC ... #Differential #
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... Hemorrhage - Differential ... . prolonged/induced ... thrombocytopenic purpura ... (DIC) • Anti-coagulation
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... - DIC (disseminated ... intravascular coagulation ... #Bruising #Causes ... pediatrics #diagnosis #differential
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... the PT remains prolonged ... discern these causes ... disease • Acute DIC
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