12 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... Causes include : ... intravascularcoagulation (DIC ... #differential #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... intravascular coagulation (DIC ... #Prolonged #Causes ... #differential #hematology
Visual Guide to AV Nodal Reentrant Tachycardia (AVNRT) - Pathophysiology
 - Dual AV nodal physiology is
Visual Guide to AV ... Nodal Reentrant ... Pathophysiology - Dual AV ... - In most case ... ECG usually shows
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT/PTT ... Treat primary cause ... INR < 2.3 - APTT ... Coagulation #diagnosis #causes ... treatment #management #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Toxic Damage (e.g ... • TTP/HUS • DIC ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Causes of Thrombocytopenia ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation (DIC ... (usually IgG) (e.g ... Extravascular #Causes ... differential #diagnosis #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... Management #treatment #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
NORMAL PT/NORMAL PTT ... Warfarin • Acute DIC ... discern these causes ... disease • Acute DIC ... Differential #Diagnosis #Hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
cryoglobulin (CG ... cryoglobulins • Negative causes ... skin necrosis • DIC ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology