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differential coagulation abnormal algorithm aptt bruising management treatment anemia atlas basics blanching bruise dermatology disseminated ecchymosis hematomas hemolysis hemolytic hemophilia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... - Disseminated intravascular ... coagulation (DIC ... hemoglobinuria (PNH) Extravascular ... #diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Disseminated intravascular ... coagulation (DIC ... #Causes #diagnosis ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... #Intravascular ... #Coagulation #diagnosis ... #management #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... - Differential Diagnosis ... Rare • Drugs (e.g ... • Disseminated Intravascular ... #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... for a Prolonged ... intravascularcoagulation (DIC ... #Causes #diagnosis ... #differential #hematology
Causes of Post-Partum Hemorrhage - Differential Diagnosis Algorithm Blood Loss: >500mL post vaginal delivery OR >1000 mL
Causes of Post-Partum ... - Differential Diagnosis ... . prolonged/induced ... • Disseminated intravascular ... coagulation (DIC
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... prolonged after ... , disseminated intravascular ... discern these causes ... #Hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
disease) • aPTT is prolonged ... normal in mild cases ... ) • PT/INR & von ... hemophilia type (e.g ... Management #treatment #hematology
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
ecchymosis) is caused ... of blood in the extravascular ... Excessive bruising & prolonged ... to be normal, PT ... Diagnosis VWF
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
considered to be caused ... flat macules of extravascular ... bruise') is where bleeding ... nettle sting #Diagnosis ... #Dermatology #Skin
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