23 results
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary Cirrhosis ... female-predominant disease ... of autoimmune disease ... Primary #Biliary #Cirrhosis ... #hepatology
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver Disease ... Primary Biliary Cirrhosis ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
) Treatment Primary ... or autoimmune disease ... transplantation for refractory ... disease - Dr. ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... diagnosis #management #treatment
Mechanisms Driving Increased Thrombosis and Bleeding in Liver Disease
Increased Thrombosis 
Increased Platelet-Vesset Wall Interaction 
 •
Bleeding in Liver Disease ... Bleeding #Clot #Cirrhosis ... #Pathophysiology ... #Hepatology #Liver
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... age, however the disease ... • Bicytopenia Treatment ... diagnosis #management #treatment ... #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
those with CLD (± cirrhosis ... months without treatment ... underlying liver disease ... Liver #Failure #Cirrhosis ... #Hepatology #gastroenterology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... 65 years PBC Pathophysiology ... cholestasis → Cirrhosis ... but elevated as disease ... diagnosis #workup #hepatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... highly inflammatory disease ... hypersensitivity syndromes • HLH ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology
Nutrition in Cirrhosis: Dos and Don’ts
Screening:
 • Patients at risk for RFH-Nutritional Prioritizing Tool
 • Low
Nutrition in Cirrhosis ... patients with liver cirrhosis ... #Nutrition #Cirrhosis ... diet #management #hepatology ... #pathophysiology