11 results
diagnosis hematology blood differential product reactions treatment ana anca antibody antineutrophil antinuclear antinxp2 antinxp2dm autoimmune causes classification coagulation dermatology dic
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... Polymyositis and dermatomyositis ... polyangiitis without renal ... Antineutrophil #antibodies ... #diagnosis #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pancreas, biliary, renal ... autoantibodies (antinuclear antibodies ... Disease #diagnosis #management ... workup #treatment #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... chest (in a V-sign ... • Clear cell renal ... #diagnosis #management ... #rheumatology #
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Bleeding (64%) • Renal ... HIT: Heparin-PF4 antibodies ... causes #treatment #management ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Still disease, dermatomyositis ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... 1, SCL-70, RNP antibodies ... anticardiolipin antibodies
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
levels • EMG DERMATOMYOSITIS ... RP-ILD), dermato-rheumatologic ... papules and Gottron sign ... ) • Shawl sign ... Myositis #Myopathy #rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Rh) & recipient antibodies ... , DIC, hypoTN, renal ... anti-platelet antibodies ... Transfusion #diagnosis #management ... #hematology #reactions
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... purpura: strong sign ... C-ANCA) pattern: antibodies ... • Urinalysis (Renal ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Rh) & recipient antibodies ... , DIC, hypoTN, renal ... anti-platelet antibodies ... Transfusions #diagnosis #management ... #hematology #reactions
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