15 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... Infection exposure (l MD ... smear, HIV/HCV testing ... cases: INR/PT, aPTT ... #hematology
4T Score for Heparin-Induced Thrombocytopenia

Interpretation of the 4T score:
0-3 points:  Low probability (<<1%)
  -
Heparin-Induced Thrombocytopenia ... - No further workup ... Consider therapeutic anticoagulation ... HeparinInduced #Thrombocytopenia ... Diagnosis #Criteria #Hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
TMA: Unexplained thrombocytopenia ... antiglobulin test, PT/aPTT ... hemosiderin • PT/aPTT ... Matthew Ho, MD ... Management #Algorithm #hematology
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
/uL Initial Workup ... iron studies, PT/aPTT ... Matthew Ho, MD ... Diagnosis #Algorithm #hematology ... #workup
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Eating disorders ... • Hypoplastic MDS ... #Pancytopenia #Workup ... Diagnosis #Algorithm #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Schistocytes, thrombocytopenia ... Diagnosis #Algorithm #workup ... #hematology #testing
Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
 1. Autoimmune Mediated Pancytopenia
 2. Splenic Sequestration
Peripheral Destruction
Pancytopenia - Workup ... Eating disorders ... • Hypoplastic MDS ... #Pancytopenia #Workup ... Diagnosis #Algorithm #Hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
platelet, PT, PTT ... Gplb receptor • Thrombcytopenia ... considered first-line testing ... Platelet #disorders #hematology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Maheswaranathan, MD ... Scleroderma #SSc #rheumatology ... signs #symptoms #testing ... #workup
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... performed PT, PTT ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology