15 results
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... ITP • SLE • CLL ... HUS • DIC • Vasculitis ... Algorithm #Causes #Hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... ) Blood (75%): Anemia ... Leucopenia/lymphopenia, Thrombocytopenia ... symptoms #diagnosis #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Schistocytes, thrombocytopenia ... cardiac valve, vasculitis ... Diagnosis #Algorithm #workup ... #hematology #testing
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... differential #diagnosis #hematology ... #anemia
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
incompetent • CLL ... • Neutropenia, anemia ... , thrombocytopenia ... Leukemia #diagnosis #workup ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... Diagnosis #Causes #Workup ... #hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... Constitutional symptoms, Arthritis ... • Immunologic Workup ... Lupusreference #druginduced ... #table #rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
recurrent fevers, vasculitis ... Abnormalities: macrocytic anemia ... , thrombocytopenia ... arteritis (4%) ... Autoinflammatory #Somatic #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... • Mesenteric vasculitis ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
SJIA], systemic lupus ... with leukopenia, anemia ... , and thrombocytopenia ... Diagnosis #Management #Hematology ... #Rheumatology