9 results
diagnosis management sle classification differential erythematosus hematology pharmacology vasculitis activation anemia aplastic comparison cryoglobulinemia cryoglobulins drugs hydroxychloroquine macrophage mas measurement
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
half-life = 40 days ([HCQI ... 200ng/mL Best indications ... Measurement #SLE #rheumatology ... #pharmacology #levels ... #lupus #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... months to years) Systemic ... life-threatening • Treatment ... Lupusreference #druginduced ... #table #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... lupus erythematosus ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... #Rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Drug Induced Systemic ... for 1 year of treatment ... Lupusreference #DrugInduced ... #medications #drugs ... differential #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... antibodies, Complement levels ... activation and/or medications ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • Infections: HCV ... C4 complement level ... lupus erythematosus ... classification #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... lupus erythematosus ... Complement (Low levels ... • HIV • HBV HCV ... differential #diagnosis #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Antithyroid medications ... - CMV - HCV ... index < 2 • EPO Level ... aplastic anemia Treatment ... Anemia #oncology #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
lupus erythematosus ... in LNs and the systemic ... immunoglobulin levels ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
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