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diagnosis hematology comparison hemolysis lymphoma management rheumatology workup anemia apml causes chronic classification dermatologic differentiation erythematosus extravascular gap globulin gpa
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
identical to the non-Hodgkin ... • M > F • Affects ... Intussusception, SIB ... diagnosis #workup #oncology ... #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... Reed Sternberg cell ... based on: - Cell ... type (B cell, T ... NonHodgkins #comparison #oncology
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... structure and cell ... Grey Platelet Syndrome ... comparison #table #differential ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
cells. ... accounts for 10% of all ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... ) (e.g. lupus, CLL ... Hemoglobinopathies (e.g. sickle cell ... Extravascular #Causes #differential
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... : Sickle cell anemia ... #Hemolysis #Differential ... #Diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
low red blood cell ... hematopoiesis cell ... blood count with differential ... #diagnosis #hematology ... #oncology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
reticularis Differential ... • Goodpasture syndrome ... • Giant cell arteritis ... Nasopharyngeal carcinoma • Hodgkin ... disease • Non-Hodgkin
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... • Induce blast cell ... initiation • Differential ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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