18 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Tests (LFTs) - ... Hepatopathy • Acute ... injury) • Ischemic ... Diagnosis #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
> 20x normal - Acute ... normal - Infection (EBV ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... C, A, E, B, D, EBV ... #Injury #Differential ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injuryliver ... Injury Differential ... #Injury #Differential ... Transaminitis #LFTs
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Elevated Transaminases ... HAV, HCV, HEV, EBV ... Trauma: Shock liver ... #Diagnosis #causes ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... of Acute Liver ... HBV, HCV, HEV, EBV ... specificity to elevated
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
of Elevated CK ... (COVID19, CMV/EBV ... Illness Myopathy (ICU ... renal injury, Strenuous ... #CK #differential
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... specificity to elevated ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... for alternative causes ... HBV, HCV, HEV, EBV ... dechallenge • Acute ... #Algorithm #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Mild jaundice, Elevated ... Syndrome (Hemolysis, Elevated ... and hemorrhage Acute ... Disease #Pregnancy #hepatology ... hepatitis #comparison #differential