57 results
Multiple Uses for Tranexamic Acid (TXA) - Evidence Based Indications and Dosing

Trauma < 3 hrs •
Thinking MTP YES ICH ... Indications #management #EBM
Rapidly Progressive Glomerulonephritis (RPGN) 
 - Loss of kidney function over a short period of tirne
Basement Membrane (GBM ... Linear, ribbon-like GBM ... staining on IF • No EM ... immune deposits, negative
Pain, Agitation, and Delirium (PAD) in the ICU
Addressing the ICU Triad (PAD) can be accomplished through
Addressing the ICU ... Richmond Agitation ... also be dosed PO Sedative ... line non-benzo sedative ... used as first sedative
Decompressive Craniectomy in Diffuse Traumatic Brain Injury (DECRA)

In adults with severe diffuse traumatic brain injury and
of stay in the ICU ... VisualAbstract #EBM
POLAR Randomized Clinical Trial - Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients
#CriticalCare #ICU ... VisualAbstract #EBM
TTH48 - Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac
admitted to the ICU ... #CriticalCare #ICU ... VisualAbstract #EBM
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Henoch-SchonIein Purpura Anti-GBM ... to Kidney: Anti-GBM ... involvement: Anti-GBM ... Pauci-immune mediated (Negative
The test characteristics of the heterophile antibody (AKA the monospot test) are not perfect and can
positive and false negative ... instead using EBV ... Mononucleosis #EBV
NICE-SUGAR - Intensive versus Conventional Glucose Control in Critically Ill Patients
N Engl J Med 2009; 360:1283-1297
adults in the ICU ... VisualAbstract #Diabetes #EBM
Airway Pressure Release Ventilation (APRV) - Early application of airway pressure release ventilation may reduce the
ventilation and ICU ... VisualAbstract #Pulmonary #EBM