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oncology rheumatology algorithm anemia aplastic apml causes cd4 classification differential differentiation dili druginduced hemophagocytic hlh hodgkins icl idiopathic liver lymphocytopenia
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Purpura (TTP) Diagnosis ... admission to the ICU ... Thrombocytopenic #Purpura #management ... #treatment #rheumatology ... #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... start and stop dates ... non-essential drug/HDS treatments ... HBV, HCV, HEV, EBV ... #hepatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Unknown cause Treatment ... of emergency, ICU ... #management #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... opacities • Diagnosis ... Renal Failure Treatment ... organ dysfuxtion, ICU ... #management #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... to BM) • Constitutional ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
CD4 Lymphopenia (ICL ... CRITERIA FOR ICL ... EBV. CMV. ... #Lymphopenia #ICL ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... - Lymphocyte rich ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management
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