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management hemophagocytic hlh lymphohistiocytosis oncology acute algorithm anemia aplastic brain classification clinical crypto cryptococcal differential dili druginduced hemeonc hepatology hiv
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Idiopathic CD4 Lymphopenia ... (ICL) / Lymphocytopenia ... CRITERIA FOR ICL ... #Lymphopenia #ICL ... #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... biologics (CMV +++, EBV ... Drugs, Unknown cause ... Treatment: • ... of emergency, ICU
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Toxic injury to BM ... and petechiae Causes ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... start and stop dates ... non-essential drug/HDS treatments ... for alternative causes ... HBV, HCV, HEV, EBV
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
during transient CD4 ... lymphopenia of ... Epstein-Barr virus (EBV ... antibody test) Treatment ... Syndrome #HIV #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... - Lymphocyte rich ... lymph node biopsy (diagnostic ... Hodgkin Lymphoma Treatment ... classification #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Infections (e.g., EBV ... of NK cells and CD8 ... Treatment Approach ... #Management #Hematology
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
immunocompromised CD4 ... Standard treatment ... survival by 25% ↑ ICP ... to normalize ICP ... approximately 15% ↑ in rate
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