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causes management cns hematology nephrology algorithm betadglucan fungal galactomannan renal treatment agglutinin aids anemia biomarkers blood brain cd4 ck classification
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... cut-offs defined in clinical ... BAL GM does not differentiate ... - Frozen ice-pops ... Galactomannan #diagnosis
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Diagnosis Framework ... : Influenza, EBV ... Rhabdomyolysis, Critical ... #Diagnosis #causes ... #neurology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
granulomatosis: • EBV-associated ... cryptococcus, and aspergillus ... Lesions #Brain #differential ... #diagnosis #causes ... #radiology #neurology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... +++: Virus (EBV, ... biologics (CMV +++, EBV ... of emergency, ICU
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
cut-offs defined in clinical ... surfaces, Albumin, Infections ... >90% (In most clinical ... in BAL does not differentiate ... Penicillium), Frozen ice-pops
Hematuria in Post-Renal Transplant Patient Prevalence up to 12% in the postrenal transplant patient • Bacterial: Escherichia
Cryptococcus Neoformans, Aspergillus ... : Secondary to infections ... (HPV, EBV), Renal ... Renal #Transplant #differential ... #diagnosis #kidney
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria - Differential ... Diagnosis Algorithm ... Glomerular Proteinuria (Positive ... proliferative • Anti-GBM ... HSP • Post-infectious
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Diagnosis for Pulmonary ... : - ANCA-positive ... allopurinol), Infection ... anti-ANCA ab, anti-GBM ... #diagnosis #nephrology
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Viruses (HSV, EBV ... Influenza A FUNGAL - Aspergillus ... Miller-Fisher GBS; Positive ... #Diagnosis #Causes ... #Neurology
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
(COVID19, CMV/EBV ... immobility • Critical ... Illness Myopathy (ICU ... #Elevated #CK #differential ... #diagnosis #rhabdomyolysis
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