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diagnosis rheumatology comparison lupus oncology sle apml aspergillus betadglucan biomarkers classification clues cppd differentiation fungal galactomannan hodgkins lymphoma syndrome system
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... Malignancy (e.g. hematologic ... to: Arthritis, Fever ... Thrombosis highest risk
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
the face (many differential ... 9) Unexplained fever ... including in children (pediatric ... clues #system #erythematosus ... #rheumatology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
and Management ... inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... drug failure • Risk
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... #Comparison #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Attempt if high risk ... Subacute-Acute: • Common: fever ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... useful in high risk ... BAL GM does not differentiate ... post-2010 almost never ... or GVHD (leaky gut
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Risk ... • Dyspnea • Fever ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
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