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diagnosis treatment fungal hematology oncology comparison galactomannan gout infectiousdiseases lung peds pulmonary abscess aids algorithm antibiotics apml aspergillus autoimmune bacterial
“Step by Step” – the new kid on the block – aims to risk stratify this
block – aims to risk ... those patients at risk ... considered “low risk ... #Pediatrics #Peds ... #Antibiotics #Risk
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... : Temperature rises ... Brucellosis Faget's Sign ... For every 1°F rise ... #Patterns #Differential
Pediatrics Sepsis Screening SIGNS OF INFECTION? • Fever (>38C) • Hypothermia (<36C) • Cough/chest pain/respiratory distress •
Pediatrics Sepsis ... OF INFECTION? ... • Fever (>38C) ... RISK MEDICAL CONDITIONS ... • Other high-risk
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
invasive fungal infection ... surfaces - Infections ... useful in high risk ... BAL GM does not differentiate ... Fungal #Biomarkers #BetaDGlucan
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Attempt if high risk ... Subacute-Acute: • Common: fever ... initiation • Differential ... Diagnosis: Infection ... APML #diagnosis #management
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... • CT: Halo sign ... Pneumonia: • Risk ... AIDS #pulmonary #differential
Spontaneous Bacterial Peritonitis DIAGNOSTICS Paracentesis: • Calculate absolute PMN count (total WBC x PMN %) • Correct
Treat if other signs ... (fever, abdominal ... small study, low-risk ... ß-blockers due to ↑ risk ... SBP • PPIs = ↑ risk
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... MUCORMYCOSIS • Risk ... • Cough, fever ... Encapsulated yeast • At risk ... Fungal #Diagnosis #Management
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... pneumonia • DM risk ... : • 80% have fever ... Intervention: - Fevers ... Lung Abscess Differential
Debridement and Management of Prosthetic Joint Infection (PJI) Duration of symptoms <3 weeks OR <30 days
Debridement and Management ... Staphylococci: 24wk for knees ... whether benefit > risk ... - Never “lifelong ... #Debridement #Management
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