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diagnosis management hematology oncology betadglucan comparison galactomannan infectiousdiseases joint lung pulmonary abscess aids apml arthritis aspergillus autoimmune biomarkers brain causes
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... noninflammatory Signs ... • Rheumatic fever ... • Lyme • Gout ... tuberculosis) • Fungi
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... drug failure • Risk ... #rheumatology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) ... surfaces - Infections ... useful in high risk ... BAL GM does not differentiate ... or GVHD (leaky gut
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
diagnose concomitant infection ... inflammatory response Risk ... forefoot, ankles, knees ... 12-24 Hours • Fever ... #Comparison #rheumatology
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... pneumonia • DM risk ... : • 80% have fever ... Intervention: - Fevers ... Prevotella • Fungal
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... in HIV - Differential ... Pseudomonas FUNGAL ... • CT: Halo sign ... Pneumonia: • Risk
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Attempt if high risk ... Subacute-Acute: • Common: fever ... initiation • Differential ... Diagnosis: Infection
Debridement and Management of Prosthetic Joint Infection (PJI) Duration of symptoms <3 weeks OR <30 days
Staphylococci: 24wk for knees ... DDIs/AEs) - Fungus ... whether benefit > risk ... - Never “lifelong ... #treatment #Debridement
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
surfaces, Albumin, Infections ... useful in high risk ... in BAL does not differentiate ... post-2010 almost never ... or GVHD (leaky gut
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... pulmonary symptoms • Rheumatologic ... MUCORMYCOSIS • Risk ... • Cough, fever ... Encapsulated yeast • At risk
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