11 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Pathophysiology ... Attempt if high risk ... Diagnosis: >3 symptoms ... #management #hematology
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Pathogenesis and Clinical ... Findings Risk ... Apolipoprotein E4 allele Risk ... mutations - Down syndrome ... AlzheimersDisease #Dementia #pathophysiology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
transfused patientsl • Risk ... factors: Critical ... ARDS to explain symptoms ... transfused patients • Risk ... Transfusion #Reactions #hematology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Pathogenesis and clinical ... Patients at Risk ... Constipation - MSK ... #diagnosis #pathophysiology ... #symptoms #signs
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
may cause severe clinical ... Risk Factors: ... overload) Other Symptoms ... hyperparathyroidism Treatment ... Differential #Diagnosis #Pathophysiology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... carries a variable risk ... factor (GCSF) treatments ... and reducing the risk ... #diagnosis #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... Risk factors 3. ... epilepticus Treatment ... underlying cause • Treatment
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Bone Groups at risk ... poor nutrition Clinical ... Psychiatric symptoms ... nonimmune hemolysis MSK ... vasculitis Treatment
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
salivary ducts Clinical ... effusion, INC risk ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Malignancy Risk
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
instability with a risk ... and are also at risk ... and the risk of ... have an elevated risk ... infection or bleeding risk