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doac hematology anticoagulant dabigatran noac coagulation management cascade oral pathophysiology pt treatment absorption afib anatomy aptt atrial bridging cardiomyopathy causes
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology
Coagulation Cascade - Actions of Anticoagulants • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin • Fondaparinux • Direct
Xa Inhibitors: Rivaroxaban ... , Apixaban, Edoxaban ... K Antagonists: Warfarin ... #anticoagulation ... #pharmacology
Choice of anticoagulant for treatment of pulmonary embolism • Malignancy - LMWH • To avoid parenteral
Choice of anticoagulant ... ; edoxaban; VKA ... #decisionaid #vte ... #anticoagulation ... #pharmacology
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Anticoagulants Common ... Reversal Agents - Warfarin ... (Praxbind) - Apixaban ... (Lixiana), Rivaroxaban ... #doac #noac #pharmacology
Xa Inhibitors - Apixaban and Rivaroxaban Oral Xa inhibitors are recommended by CHEST as first-line for
Fibrillation requiring anticoagulation ... indications and edoxaban ... patients with normal ... #Rivaroxaban #Dosing ... #Pharmacology
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents Warfarin - 100% Hepatic, 0% Renal Apixaban
Clearance of Oral Anticoagulant ... Agents Warfarin ... Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... Hepatic, 50% Renal Rivaroxaban
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing Renal Dosing: Apixaban (25% renal clearance):
: Apixaban (25% ... if CrCl < 50) Edoxaban ... OralAnticoagulant #Anticoagulation ... #Hematology #Pharmacology ... #Apixaban #Rivaroxaban
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Clotting Time Warfarin ... Fondaparinux Rivaroxaban ... Apixaban, Edoxaban ... #Tests #Anticoagulation ... #Testing #Diagnosis
Anticoagulant Sites of Absorption Apixaban - Primarily proximal small intestine; some gastric absorption Dabigatran - Lower stomach and
of Absorption Apixaban ... and duodenum Edoxaban ... small intestine Rivaroxaban ... gastric absorption Warfarin ... #anatomy #pharmacology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Pathophysiology Anticoagulation ... the mainstay of VTE ... (e.g. warfarin) ... #Pharmacology #Pathophysiology ... DOAC #Dabigatran #Apixaban
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