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rheumatology neurology differential gravis lupus myasthenia syndrome systemic activation algorithm ana antinuclear arthritis arthropathies arthropathy autoantibodies checklist communication discharge disease
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... activity Anti-Ro ... #SLE #Summary #diagnosis ... #rheumatology #management
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... Erythematosus ( ... SLE), should have ... Amy Chung, MD, MSc ... Joint #Disorders #msk
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
40% Target: SS-A/Ro ... -15% If SLE is clinically ... suspected, tests ... #erythematosus ... #diagnosis #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... erythematosus ( ... should be obtained ... (to support a diagnosis ... ANA and RF (if clinical
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus ... erythematosus [ ... Liver function tests ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
: • Based on clinical ... anti—muscle-specific kinase (MuSK ... antibodies - MuSK-positive ... - Improves clinical ... #management #neurology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
myasthenia Diagnosis ... Bedside: ice pack test ... /Edrophonium test ... immunologic assay - MuSK ... #management #neurology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... NMO-IgG (anti-AQP4) should ... negative, MOG-IgG test ... should be ordered ... #management #neurology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
and Management ... renal failure Clinical ... skin (16-32%): lupus ... anterior/posterior MSK ... #Management #Signs
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Antibodies: Anti-Ro ... Antibodies: • Anti-Ro ... salivary ducts Clinical ... phenomenon (16%) MSK ... #Management
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