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neurology differential rheumatology treatment als amyotrophic antinxp2 antinxp2dm autoimmune cerebritis cns dermatology dm erythematosus hematology lateral leukostasis lupus lysis muscle
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Elevations of serum ... • Inflammatory myopathy ... polymyositis, dermatomyositis ... Atorvastatin Diagnosis ... #diagnosis #management
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... enzyme levels in serum ... Polymyositis #PM #Diagnosis ... #Pathophysiology ... #Signs #Symptoms
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... Muscle Biopsy: Dermatomyositis ... #Differential #Diagnosis ... #neurology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Aseptic Meningitis, Myelopathy ... Disease, PRES Pathophysiology ... permeability Diagnosis ... Erythematosus #SLE #CNS #neurology ... #management #treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... contents into serum ... Syndrome #TLS #diagnosis ... #management #hematology
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... of UMN and LMN signs ... EMG: LMN Signs in ... Lateral #Sclerosis #neurology ... #diagnosis #management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... or tenderness; serum ... myopathies Diagnostic ... papules and Gottron sign ... ) • Shawl sign
Scleroderma Renal Crisis - Diagnosis and management Diaqnosis • De novo arterial hypertension of normotensive form +++
and management ... Diaqnosis • ... • Increased serum ... creatinine >50% • Signs ... #management #nephrology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... the spinal cord (Myelopathy ... bouts of HTN Diagnostic ... • Bilateral signs ... #management #neurology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... shoulders (in a shawl sign ... levels of: • Serum ... : • ILD was diagnosed ... #diagnosis #management
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