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differential potassium high management pharmacology renal algorithm binders binding comparison diuresis diuretics encephalopathy excretion hypokalemia hyponatremia hypotonic managment modalities modes
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding Agents ... obtain the desired serum ... Side Effects: Edema ... #medications #pharmacology ... #table #comparison
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... transfusion • HTN and edema ... Medications 2. ... #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
Diagnosis Framework ... transfusion • HTN and edema ... Medications 2. ... #causes #potassium ... #high #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... only if no clear cause ... Elimination (see Table ... caution in HTN & edema ... Treatment #potassium #nephrology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Immunosuppressive agents ... Blood transfusion, Hypercalcemia ... Electrolyte abnormality, Medication ... the underlying cause ... with AEDs until cause
Renal Replacement Therapy (RRT) - ICU One Pager Summary Indications (AIEOU): • A: Acidosis (usually severe metabolic)
derangements (hyperkalemia ... , hypercalcemia, ... Overload (pulmonary edema ... chosen to match serum ... #managment #nephrology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
Diuretics and Agents ... Hyponatremia • Hypercalcemia ... Kidney stones caused ... #Pharmacology #Medications ... #Table
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
algorithm Urine Na+K ... / serum Na >1 is ... #differential #diagnosis ... #table #sodium ... #nephrology
Pragmatic diagnostic algorithm for hypokalemia. ***Typical presentations: • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic ... Tubulopathy: urine K/ ... after correcting serum ... Other medications ... #algorithm #nephrology
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