6 results
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
Inherited Defects ... renal tubular acidosis ... Nephrogenic diabetes insipidus ... Defects #Kidney #Nephrology ... #Diagnosis #Differential
Hyponatremia Differential Diagnosis Algorithm - Utilizing Uric Acid 
ADH promotes Urea/uric acid excretion along with water
Hyponatremia Differential ... water retention 1) Serum ... 4) Serum Uric Acid ... salt wasting By Rachel ... Diagnosis #Algorithm #nephrology
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Hypernatremia - Differential ... free water loss, Serum ... Sodium >145 mmol ... kg • Diabetes Insipidus ... Hypernatremia #Nephrology
Diabetes Insipidus - Diagnosis Algorithm
Tests:
 • Osmolality, Urine AND/OR
 • Osmolality, Serum or Plasma AND
 •
Diabetes Insipidus ... Plasma AND • Sodium ... ARUPLabs #Diabetes #Insipidus ... Diagnosis #Algorithm #nephrology ... #differential
Primary Polydipsia
Definition: Excessive volitional water intake
Epidemiology:
 • 6-20% of patients with psychiatric disorders - Most commonly
Differential Diagnosis ... : Diabetes Insipidus ... Initial Workup: Serum ... Sodium, Urine Sodium ... diagnosis #management #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Inherited (AR) ... thiazide-sensitive sodium ... ratio 0.5%) Differential ... Renal tubular acidosis ... Syndrome #diagnosis #nephrology