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SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... • Pustular skin ... suppurativa, palmar pustular ... pustulosis, pustular ... Rule out other causes
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
Pustular Skin Lesions ... • Pustules < 5-10 ... Rosacea Pustular ... Erosive pustular ... SAPHO syndrome (
Pustular Skin Rash - Differential Diagnosis Algorithm Pruritic / Scaly / Erythematous lesions, usually poorly demarcated Acneiform -
Pustular Skin Rash ... Folliculitis - Pustules ... thick honey-yellow crusts ... with satellite pustules ... Diagnosis #Algorithm #causes
Fluid-filled Rash - Diagnostic Algorithm. Pustule: 1) Pustules more commonly suggest an infectious process (bacterial,
Pustule: 1) Pustules ... FluidFilled #Vesciular #Pustular
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture ... antibiotics as a cause ... Auto-Inflammatory: PAPA, SAPHO ... Auto-Inflammatory: SAPHO
Drugs Causing Acute Pancreatitis Class Ia: The medications in which there was a rechallenge and other causes
rechallenge and other causes ... out other common causes ... Class II: Cases ... and atleast4 case ... #Pancreatitis #Causes
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
Causes of Peripheral ... • Progressive muscular ... Neuropathy • Spinal Muscular ... Polymyositis • Duchenne Muscular ... Diagnosis #Algorithm #Causes
ID Ddx: Diarrhea in a transplant recipient - Bacterial: C.diff, Campy, Salmonella, Aeromonas, E.coli - Viral: CMV, noro,
Viral: CMV, noro, sapo ... Transplant #TxID #SOT #Causes
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
erythema and erosive pustules ... Blenorrhagicum - pustular
Causes of Erythema Nodosum - Mnemonic NO cause found in 60% of cases Drugs (antibiotics e.g., sulfonamides, amoxicillin) Oral
Causes of Erythema ... Mnemonic NO cause ... found in 60% of cases ... Nodosum #Mnemonic #Causes
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