39 results
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
Clinical Trials of SGLT2 ... ASCVD; signal for SGLT2i ... risk; signal for SGLT2i ... outcomes in HFrEF on GDMT ... outcomes in HFrEF on GDMT
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
-4 inhibitors SGLT2 ... Improved outcomes in CKD ... endocrinology #dm2
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Definitions of AKI, CKD ... Kidney Disease (CKD ... ml/min per 1.73 m2 ... ml/min per 1.73 m2 ... ml/min per 1.73 m2
Diabetes Combination Tablets - Estimated A1c Lowering 
Metformin + DPP4 
• Janumet (metformin + sitagliptin) 
•
Metformin + SGLT2 ... dapagliflozin) Dpp4 + SGLT2 ... Tablets #Oral #DM2
Guideline-Directed Medical Therapy (GDMT) in HFrEF and CKD

 • Class I pillars of HFrEF GDMT across
Medical Therapy (GDMT ... ) in HFrEF and CKD ... pillars of HFrEF GDMT ... diuretics, MRA, SGLT2i ... #CKD #HFrEF #management
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy - Initiation Strategies

 •
Beta-Blocker → MRA → SGLT ... Beta-Blocker + SGLT ... Guideline #management #GDMT
Guidelines Directed medical therapy for Heart Failure 

Satyendra Dhar, MD, @DharSaty

#HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
DharSaty #HFrEF #GDMT ... sodium-glucosecotransporter-2inhibitors #SGLT2i
Diabetes Type 2 Medication Management and Titration Algorithm
- First line therapy is metformin and comprehensive lifestyle
Established ASCVD or CKD ... established ASCVD or CKD ... #Diabetes #DM2
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
drugs Other than SGLT2i ... metformin in T2D and CKD ... receptor agonist SGLT2i ... , #KDIGO2020 #CKD ... Management in CKD
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy
 • Beta-blocker
 • ACE,
ARNI • MRA • SGLT ... Guideline #management #GDMT