19 results
Selected Clinical Trials of SGLT2 inhibitors in CVD and CKD
EMPA-REG OUTCOME - Empagliflozin lowered CV events
inhibitors in CVD ... HF outcomes in HFrEF ... on GDMT, with or ... HF outcomes in HFrEF ... on GDMT, with or
Guideline-Directed Medical Therapy (GDMT) in HFrEF and CKD

 • Class I pillars of HFrEF GDMT across
Medical Therapy (GDMT ... ) in HFrEF and CKD ... GDMT across the ... diuretics, MRA, SGLT2i ... #CKD #HFrEF #management
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy
 • Beta-blocker
 • ACE,
Ejection Fraction (HFrEF ... ARNI • MRA • SGLT ... #Failure #CHF #HFrEF ... Guideline #management #GDMT
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy - Initiation Strategies

 •
Ejection Fraction (HFrEF ... Beta-Blocker → MRA → SGLT ... Beta-Blocker + SGLT ... #Failure #CHF #HFrEF ... Guideline #management #GDMT
Stages in the development of HF and recommended therapy by stage. ACEI indicates angiotensin-converting enzyme inhibitor;
angiotensin-receptor blocker; CAD ... resynchronization therapy; DM ... ejection fraction; GDMT ... ejection fraction; HFrEF ... Stages #ACCAHA #Algorithm
Guidelines Directed medical therapy for Heart Failure 

Satyendra Dhar, MD, @DharSaty

#HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
@DharSaty #HFrEF ... #GDMT #sodium-glucosecotransporter ... -2inhibitors #SGLT2i
Diabetes Medications Summary Table
Insulin
Lifestyle modifications
Metformin
Sulfonylureas
GLP-1 receptor agonists - ↓ major adverse CV events
TZDs
DPP-4 inhibitors
SGLT2 inhibitors -
major adverse CV ... -4 inhibitors SGLT2 ... major adverse CV ... Improved outcomes in CKD ... endocrinology #dm2
Oral Antihypertensive Medications - Selection by Comorbidities
Comorbidities: 
 • Stable Angina, HFpEF, HFrEF, AFib, TAA/Marfan, Aortic
Stable Angina, HFpEF ... , HFrEF, AFib, TAA ... Dissection • CKD ... , DM, ESRD, PKD
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... Action: Inhibits SGLT2 ... canagliflozin ↓ CV ... mL/minute/1.73 m2 ... Pharmacology #Summary #DM2
Diabetes Type 2 Medication Management and Titration Algorithm
- First line therapy is metformin and comprehensive lifestyle
and Titration Algorithm ... Established ASCVD or CKD ... established ASCVD or CKD ... #Diabetes #DM2 ... Medication #Management #Algorithm