9 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Positive ANAAutoimmune ... : The ANA patterns ... #Antibodies #ANA ... #patterns #rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... SLE), Sjogren's Syndrome ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... 30-40% Target: SS-A ... SLE-SSc-AlM overlap syndromes ... Lupusreference #Antinuclear ... erythematosus #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
disease • Non-autoimmune ... Malignancy (e.g. hematologic ... deficiencies • Autoimmune ... lymphopenia, low PLT • Anemia ... 1, SCL-70, RNP antibodies
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... ab • RF • Antinuclear ... antibodies ≥ 1: ... Nephrogenic DI Hematologic ... Diagnosis #Management
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
OnePager Summary Autoimmune ... ANCA vasculitis ... EGPA) • Auto-antibodies ... • IF staining patterns ... differential #diagnosis #management
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Antisynthetase syndrome ... slow onset and pattern ... #Autoimmune ... Myositis #Myopathy #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Malignancies ▪ Autoimmune ... - Cytopenias (anemia ... Infections, malignancy, autoimmune ... inhibitors, anti-IFN-γ antibodies ... #Hematology #HemeOnc
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
cartilage in the body (Autoimmune ... Anti-Matrilin-1 Ab ○ Antibodies ... Nonspecific ↑ ESR, CRP, ANA ... Polychondritis #rheumatology ... #diagnosis #management