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Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN)

Nikolsky's sign is a clinical dermatological sign which is present
Nikolsky's sign is a clinical ... differentiating between the diagnosis ... PhysicalExam #Video #Clinical ... #SJS #skin
Tweetorial - Stevens Johnson Syndrome (SJS)

By Dr. Steven Chen @DrStevenTChen

#StevensJohnsonSyndrome #SJS #Dermatology #Diagnosis #Tweetorial #Pathphysiology
Johnson Syndrome (SJS ... StevensJohnsonSyndrome #SJS ... #Dermatology #Diagnosis
Stevens-Johnson syndrome (SJS), Toxic epidermal necrolysis (TEN) and Overlap

 SJS-TEN overlap and TEN - Surface Epidermal
Stevens-Johnson syndrome (SJS ... and Overlap SJS-TEN ... Distinguishing Features #SJS ... Necrolysis #Comparison #Diagnosis
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
pattern: - SjS ... Raynaud phenomenon, SjS ... PBC/SSc OS, PBC/SjS ... polar: - SLE, SjS ... #differential #diagnosis
DRESS Syndrome vs SJS/TEN
DRESS
 • Latency: 2-8 weeks
 • Rash: Morbilliform
 • Mucosal involvement: 50% have
DRESS Syndrome vs SJS ... lymphocytes and eos SJS ... DRESS #Syndrome #SJS
ID Approach to Fever and Rash - Diagnostic Algorithm
Central Maculopapular (most common):
Measles, Parvovirus 819 / EBV,
Fever and Rash - Diagnostic ... (Strep/Staph), SJS ... or Pustular: SJS ... Rash #Febrile #Diagnosis
Types of hypersensitivity reactions

Type I - lgE-Mediated, Within I Hour (Anaphylaxis)
Type II - IgG or IgM
to Weeks (Rash, SJS ... Classification #Allergy #Diagnosis
Severe Drug Rashes - Comparison - DRESS | SJS/TEN | AGEP | Erythroderma

DRESS 
 - Onset:
Comparison - DRESS | SJS ... target lesions SJS
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
- Differential Diagnosis ... Noninfectious: SJS ... #Differential #Diagnosis
Gastrointestinal tract absorption. 

#Absorption #Nutrient #Mineral #Vitamin #Duodenum #Ileum #Jejunum #Location #Map #Gastrointestinal #Diagnosis #ShortGut #SBS
Gastrointestinal #Diagnosis ... #ShortGut #SBS