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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic ... Microangiopathies #Systemic ... Erythematosus #SLE #hematology ... #rheumatology # ... differential #diagnosis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
SHARP - Lupus Diagnosis ... D Discoid Rash ... IMDAMNSHARP #sle #systemic ... erythematosus #rheumatology ... #diagnosis #mnemonic
Maculopapular Rashes - THE ALGORITHMIC APPROACH 

The term maculopapule is a portmanteau, a combination
of macule and
and systemic toxicity ... differential diagnosis ... dependent upon systemic ... pathognomonic for SJS ... #Diagnosis #Dermatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
• Homogeneous: Systemic ... ) • Speckled: Systemic ... Sjogren's Syndrome (SS ... ANA #patterns #rheumatology ... #diagnosis #differential
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Manifestations of Systemic ... Erythematosus (SLE) #Systemic ... Signs #Symptoms #Rheumatology ... #Diagnosis
Fever and Rash - Differential Diagnosis Framework
 • Viral: Measles, Infectious Mono (EBV, CMV), Acute HIV,
Fever and Rash - ... Differential Diagnosis ... Noninfectious: SJS ... SCVMCMed #Fever #Rash ... #Differential #Diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... can present with rash ... including heliotrope rash ... /full triad at diagnosis ... #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Photosensitivity, Butterfly rash ... joints Nervous system ... signs #symptoms #diagnosis ... #rheumatology
Types of hypersensitivity reactions

Type I - lgE-Mediated, Within I Hour (Anaphylaxis)
Type II - IgG or IgM
Days to Weeks (Rash ... , SJS) - Amelia ... Classification #Allergy #Diagnosis
ID Approach to Fever and Rash - Diagnostic Algorithm
Central Maculopapular (most common):
Measles, Parvovirus 819 / EBV,
Approach to Fever and Rash ... - Diagnostic Algorithm ... (Strep/Staph), SJS ... or Pustular: SJS ... #Febrile #Diagnosis