11 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Cerebrovascular Disease ... #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Initial screening test ... Treatment: • ... Summary #diagnosis #rheumatology ... #management
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
brain, eye, and ear ... nervous system (CNS ... diagnosis and treatment ... Systemic lupus erythematosus ... BEE #Syndromes #neurology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
skin injury) • Neurologic ... Giant retinal tears ... Arthritis, AS Treatment ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
nervous system (CNS ... Liver function tests ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... negative, MOG-IgG test ... Transverse Myelitis Treatment ... Myelitis #diagnosis #management ... #neurology #differential
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
• 8%-27% for CNS ... Adenocarcinoma Treatment ... Symptomatic: artificial tears ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
affects the skin, neurologic ... ischemia • Skin: Erythematous ... cognitive impairment, neurologic ... chorioretinitis, CNS ... Differential #Diagnosis #Rheumatology
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
systemic lupus erythematosus ... histopathologic changes in LNs ... Hypoalbuminemia Treatment ... TAFRO #diagnosis #management ... #rheumatology #
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
pulmonary symptoms • Rheumatologic ... extrapulmonary disease ... especially the CNS ... MC: CNS CSF: • ... Fungal #Diagnosis #Management