16 results
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... and Medication ... medications and ... #Pathophysiology ... #Drug #Endocrinology
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing ... decongestants) • Any drug ... antihistamines, TCAs, SSRIs ... #Drugs #pharmacology ... #differential #diagnosis
Drugs causing hyperkalemia
 • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly
 •
Drugs causing hyperkalemia ... Cyclosporine, tacrolimus, Diabetes ... Drospirenone #Drugs ... #hyperkalemia #medications ... #differential #diagnosis
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Inhibitors Increasing Indications ... Significant Adverse Drug ... level < 200 mg/dL Pathophysiology ... Ketoacidosis #EuDKA #diagnosis
Secondary causes of Hypertension
 • Medications, Drugs, Chemo: NSAIDS, Steroids, CNI, Alcohol, Cocaine, OCP, Licorice, MAOI,
Hypertension • Medications ... , Drugs, Chemo: ... Pseudopheochromocytoma - respond to SSRIs ... #differential #diagnosis
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... #differential #diagnosis ... #pathophysiology ... pharmacology #potassium #medications
Causes of Hypomagnesemia
Redistribution:
 - IV glucose
 - Correction of diabetic ketoacidosis
 - IV hyperalimentation
 - Refeeding
Correction of diabetic ... renal disease Drugs ... Hypomagnesemia #Causes #diagnosis ... #differential #medications ... #drugs #pharmacology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Differential Diagnosis ... reactions Common Drugs ... (Uncontrolled diabetes ... Medications 2. ... #differential #diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
allergies, and drug ... dermatitis, type I diabetes ... Classification #Pathophysiology ... #Allergy #Diagnosis
Drug-Induced Urinary Retention

Drug-induced urinary retention is very common and can be caused by many classes of
Drug-Induced Urinary ... Retention Drug-induced ... many classes of medication ... blockers • SSRI/SNRI ... #differential #diagnosis