9 results
Diabetes Pathophysiology and Medication Targets

The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... and Medication ... medications and ... #Pathophysiology ... #Drug #Endocrinology
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
Antihypertensive Drugs ... (ACEI, ARB, diabetes ... failure - Co-medication ... Pgp-dependent drugs ... antihypertensive #medications
Drugs causing hyperkalemia
 • Impaired release of renin: NSAIDs, Beta blockers, Cyclosporine, tacrolimus, Diabetes, Elderly
 •
Drugs causing hyperkalemia ... Cyclosporine, tacrolimus, Diabetes ... Drospirenone #Drugs ... #hyperkalemia # ... medications #causes
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... Hyperkalemia ... MunerMohamed1 #hyperkalemia ... differential #diagnosis #pathophysiology ... pharmacology #potassium #medications
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... reactions Common Drugs ... Causing Hyperkalemia ... (Uncontrolled diabetes ... Medications 2.
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... reactions Common Drugs ... Causing Hyperkalemia ... (Uncontrolled diabetes ... Medications 2.
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Euglycemic Diabetic ... Inhibitors Increasing Indications ... Significant Adverse Drug ... level < 200 mg/dL Pathophysiology ... #Euglycemic #Diabetic
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Blood transfusion, Hypercalcemia ... Etiology: • Pathophysiology ... Electrolyte abnormality, Medication ... /Drug toxicity,
Serotonin Syndrome: Pathogenesis and Clinical Findings
Serotonin Syndrome: Variable combination of mental status changes, autonomic instability, and
to hours) after medication ... cessation of offending medication ... Agents: SSRls, SNRls ... weight loss agents, drugs ... Serotonin #Syndrome #Pathophysiology