18 results
IBS-D Pharmacotherapy

Loperamide
Rifaximin
Eluxadoline
Alosetron
Antispasmodics
Tricyclic antidepressants
SSRIs

#IBSD #IBS #Diarrhea #Irritable #Bowel #Syndrome #pharmacology #table #comparison #management #treatment
antidepressants SSRIs ... Diarrhea #Irritable #Bowel ... #Syndrome #pharmacology ... #table #comparison
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
• Serotonin Syndrome ... Akathisia • SSRI ... Dizziness - Nausea ... sensations) #SSRIs ... Serotonin #Inhibitors #Pathophysiology
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Reuptake Inhibitors(SNRIs ... Vomiting Serotonin Syndrome ... gain Incr NE: Nausea ... Dry Mouth #SNRIs ... SerotoninNorepinephrine #Inhibitors #Pathophysiology
Characteristics of Serotonin Syndrome and Other Hyperthermic Syndromes 
Serotonin Syndrome
 - SSRIs, second-generation antidepressants, MAOIs, linezolid,
Serotonin Syndrome ... - SSRIs, second-generation ... hyperthermia, hyperactive bowel ... normal or reduced bowel ... Diagnosis #Comparison #Table
Secondary causes of Hypertension
 • Medications, Drugs, Chemo: NSAIDS, Steroids, CNI, Alcohol, Cocaine, OCP, Licorice, MAOI,
Secondary causes ... Pseudopheochromocytoma - respond to SSRIs ... Other Endocrine causes ... low renin HTN causes ... #Secondary #causes
Causes of Hyperpyrexia (Temp > 106.7° F) - Differential Diagnosis
 • Heat Stroke
 • Drug-induced: Amphetamines,
Causes of Hyperpyrexia ... • Serotonin syndrome ... : SSRIs, MAOIs, ... Differential #Diagnosis #Causes
Hyponatremia - Differential Diagnosis by Mechanism
Decr Blood Pressure (“Decr Effective Circulating Volume”) 
 - Volume depletion
- Cirrhosis Syndrome ... cyclosporine, SSRIs ... Differential #Diagnosis #Table ... #Causes #Sodium
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
treat underlying cause ... cirrhosis, nephrotic syndrome ... Stress, Nausea, ... Meds (Opiates, SSRIs
IBS-C Pharmacologic Therapies and Recommendations
Linaclotide, Plecanatide, Lubiprostone, PEG laxatives, Tegaserod, Rifaximin, Eluxadoline, Alosetron, Loperamide, TCAs, SSRIs,
Loperamide, TCAs, SSRIs ... IBSC #irritable #bowel ... #syndrome #constipation
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
Cauda Equina Syndrome ... Causes: • Large ... soon as bladder/bowel ... #CaudaEquina #Syndrome ... #MSK #pathophysiology