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management syndrome differential activation apml ascites differentiation dili disease disorders druginduced eosinophil eosinophilia essential et hemophilia hepatitis hepatobiliary injury leukostasis
Hepatobiliary Manifestations of Sickle Cell Disease Acute sickle cell hepatic crisis: • Fever, acute onset RUQ pain,
hepatic crisis: • Fever ... Supportive with treatment ... of SCD crisis ... Hepatobiliary #hepatology ... #differential #diagnosis
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... glucocorticoid treatment ... signs or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... Algorithm DILI ... non-essential drug/HDS treatments ... Liver #Injury #Diagnosis ... #Algorithm #hepatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
hemophilia type (e.g ... by a hemophilia treatment ... Avoid meds that ... #Management #treatment ... #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... organ damage • Treatment ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Prednisone 5mg/kg ... Subacute-Acute: • Common: fever ... Renal Failure Treatment ... #management #hematology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Splenomegaly Diagnosis ... A conclusive diagnosis ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... #hematology
Refractory Ascites - Ascites that cannot be mobilized or early recurrence that cannot be prevented Diuretic Resistant:
Weight loss of <0.8 kg ... Refractory #Ascites #diagnosis ... #management #algorithm ... #treatment #hepatology
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