176 results
Pressors and Inotropes

Norepinephrine
 • alpha1 > beta 1
 • Increase SVR > Inotropy
Vasopressin
 • V1
 •
1 • Increase SVR ... V1 • Increase SVR ... 1 • Increase SVR ... Inotropy > Increase SVR ... Inotropy, Decrease SVR
Shock Classification and Differential Diagnosis
SHOCK
 • MAP <65, SBP <90, drop in SBP > 40
 •
High CO / Low SVR ... Low CO / High SVR ... Low CO / High SVR ... Low CO / High SVR
Shock - Differential Diagnosis Framework
MAP = CO x SVR
Hypovolemic (↓ Intravascular volume):
 • Hemorrhage, dehydration due
Framework MAP = CO x SVR ... third-spacing • ↓ CO, ↑ SVR ... arrhythmia • ↓ CO, ↑ SVR ... PAH • ↓ CO, ↑ SVR ... toxins • ↑ CO, ↓ SVR
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
Increases BP, SVR ... Increases BP, SVR ... Increases HR, SVR ... Increases BP, SVR ... vasoconstriction, SVR
Calcium Channel Blockers - Dihydropyridines vs Non-Dihydropyridines
Dihydropyridines (amlodipine, felodipine, nifedipine, nicardipine)
 • SVR: Decrease
 • Inotropy:
nicardipine) • SVR ... verapamil) • SVR
Syncope in 3 Steps
1. Consider the 3 "S" Mimics: Seizure, low Sugar, Stroke (TIA)
2. Heart vs
Heart vs SVR Heart ... > fast or slow SVR
Simplified Vasopressors and Inotropes Comparison Chart
MAP = CO x SVR
Dobutamine - Norepinephrine - Epinephrine - Phenylephrine
Chart MAP = CO x SVR
Tetralogy of Fallot - Hypoxic Spell Management
1. Oxygenation
2. Increase SVR
3. Abolish Hyperpnea
4. Correct Acidosis

- Dr. Rasha
Increase SVR 3.
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
High CO / Low SVR ... Low CO / High SVR
Vasopressors and Inotropes - Comparison Table
Activity: Alpha-1, Beta-1, Dopamine, SVR, HR, CO, BP
Phenylephrine
Vasopressin
Norepinephrine
Epinephrine
Dopamine
Dobutamine
Isoproterenol
Milrinone

- Dr. Eric Strong
Beta-1, Dopamine, SVR