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diagnosis hepatology differential liver injury management ascites gastroenterology saag syndrome aclf albumin bariatric bypass chronic complications dili druginduced failure gap
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Brain Failure Lung ... Failure Infections Alcohol-Associated
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... Hemochromatosis • Wilson's Disease ... Inflammatory • Alcoholic ... Primary Biliary Cirrhosis ... #Causes #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... HSV • Toxic: Alcohol ... Medication, Pregnancy, Alcoholic ... #Acute #algorithm ... #hepatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... Inflammatory: • IBD ... disorders • Celiac disease ... effect following treatment ... #Causes #Hematology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
Causes of Ascites ... - Cirrhosis ... - Alcoholic hepatitis ... fibrosis - Acute ... #differential #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• NAFLD • Alcohol ... • Cholestatic disease ... hepatitis • Drugs ... Infiltrative • Cirrhosis ... #Causes
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
HTN: ascites (SAAG ... /acute hepatitis ... • Infiltrative diseases ... Veno-occlusive disease ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... CA, small cell lung ... ALT Ratios: • Alcoholic ... : < 1 • Cirrhosis ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... HEV, EBV, CMV), Alcohol-related ... liver disease, ... dechallenge • Acute
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
>1.1 g/dl): - Cirrhosis ... - Alcoholic hepatitis ... Veno-occlusive disease ... - Acute fatty ... ascites without cirrhosis
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