46 results
Purple Urine Bag Syndrome
Chronic, indwelling catheter + bacteriuria (Providencia, Klebsiella, E.coli*) + alkaline urine
Tryptophan → Indoxyl
Purple Urine Bag ... Purple #Urine #Bag ... Syndrome #PUBS #pathophysiology ... #clinical #photo
Signs of Graves disease: 
• Goiter 
• Periorbital edema 
• Non-pitting edema causing hyperpigmented plaques 
•
Signs of Graves ... disease: • Goiter ... ) #Graves #disease ... #Signs #Clinical ... #Photo #Diagnosis
The diagonal crease in the lobe of the ear (Frank's sign) is a sign theoretically related
coronary artery disease ... groove and coronary disease ... could be useful in clinical ... #Earlobe #Clinical ... #Photo
Terry's Nails

Proximal paleness extending halfway up the nail, often eliminating the lunula. Darker distal band. Seen
advanced age, liver disease ... #PhysicalExam #Clinical ... #Photo #Sign
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... in GBA1 gene Clinical ... #Gauchers #Disease ... #Diagnosis #Signs
Brudzinski’s Sign in Meningitis (first described in 19th century by Dr. Josef Brudzinski)

Brudzinski's sign is characterized
Brudzinski’s Sign ... Brudzinski's sign ... While the pathophysiology ... despite severe disease ... #Meningitis #Clinical
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... Pathogenesis and Clinical ... the etiology Signs ... GravesDisease #pathophysiology ... endocrinology #symptoms #signs
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
>10 mmHg - clinically ... significant portal HTN Signs ... HTN: ascites (SAAG ... • Infiltrative diseases ... Veno-occlusive disease
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer’s Disease ... Pathogenesis and Clinical ... chromosome 21) Signs ... AlzheimersDisease #Dementia #pathophysiology ... geriatrics #diagnosis #signs
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Pathogenesis and Clinical ... rare, gestational diseases ... Signs/Symptoms: ... endocrinology #pathophysiology