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diagnosis hematology hellp obstetrics pregnancy ttphus anemia defects extravascular hemolysis hemolytic hyperthermic inherited intravascular leukemia mds monoclonal myelodysplasia myelodysplastic obgyn
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Thrombocytopenia ... ) Three syndromes ... child * Severe cases ... #diagnosis #table ... #comparison
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Thrombocytopenia ... Pregnancy Three syndromes ... TTPHUS #HELLP #AFLP ... #Diagnosis #Comparison ... #Table
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... Grey Platelet Syndrome ... Platelet #Defects #comparison ... #table #differential ... #diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... microangiopathy: Thrombotic thrombocytopenic ... #differential # ... diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
platelet count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... compounds, alcohol, lead ... blood count with differential ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
myopathy • Anti MAG ... Autoantibodies: • WAIHA • CAD ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... -> AML: Blast crises ... infiltrates (anemia, thrombocytopenia ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Hyperthermic Toxidromes Five toxidromes may present with overlapping features: hyperthermia, rhabdomyolysis, altered mental status/seizures. • Sympathomimetic -
• Serotonin Syndrome ... pharmacogenetic disease caused ... Hyperthermic #Toxidromes #comparison ... #table #diagnosis ... #differential #
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