11 results
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... polymorphism • Satellite ... differential #diagnosis #dermatology ... #oncology #clinical ... #skin
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... cytopenias (usually anemia ... transformation to acute leukemia ... BrighamChiefs #Myelodysplastic ... #treatment #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
• Xerosis (dry skin ... renal failure/uremia ... • Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... #generalized #dermatology
Leukemic skin Infiltrate: Patient with known Acute Myelogenous Leukemia presented with diffuse
bullous lesions (not shown). These
Leukemic skin Infiltrate ... UCSD Catalog of Clinical ... Images #Clinical ... #Photo #Dermatology ... #SkinRash #Leukemic
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... • Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... Headaches • Pale skin ... • Hypocellular myelodysplastic ... virus (EBV) • Leukemia ... #diagnosis #management
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... Orange or Hep C Clinical ... Hepatomegaly • Skin ... • Neutropenia, anemia ... workup #oncology #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... renal failure/uremia ... • Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... #generalized #dermatology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
immunophenotype Clinical ... 5) Symptoms of anemia ... marrow failure with anemia ... #oncology #hematology ... hemeonc #diagnosis #management
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
intrinsic factor, IF) Clinical ... , yellow skin, cognitive ... palpitations), skin ... diagnosis e.g. leukemia ... Deficiency #diagnosis #management