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diagnosis hematology oncology differential algorithm causes secondary generalized mds pruritus systemic aplastic cancer chronic clinical cll cutaneous gap globulin lymphocytic
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
associated with myelodysplastic ... most frequent skin ... polymorphism • Satellite ... #diagnosis #dermatology ... oncology #clinical #skin
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... cytopenias (usually anemia ... transformation to acute leukemia ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... • Aplastic Anemia ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #hematology #oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
renal failure/uremia ... • Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #generalized #dermatology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... • Hypocellular myelodysplastic ... virus (EBV) • Leukemia ... #oncology #hematology ... #diagnosis #management
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... • Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric ... #generalized #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... • Richter’s Syndrome ... • Sezary syndrome ... workup #oncology #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic ... syndromes current ... syndromes (MDS) ... acute myeloid leukemia ... disease tolerate anemia
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