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diagnosis hematology oncology causes differential secondary algorithm generalized mds pruritus aplastic chronic erythematosus hemeonc hemophagocytic hlh lupus lymphocytic lymphohistiocytosis myelodysplasia
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
== Primary Skin ... Skin Lesion / Systemic ... • Lymphoma • Leukemia ... Throbocythemia • Myelodisplastic ... #generalized #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... - infiltrates (anemia ... + distinctive primary ... -> Invade Skin: ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... Post-splenectomy Primary ... vera (PV) • Myelodysplastic ... Chronic myeloid leukemia ... (CML) - Dr.
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Hepatomegaly • Skin ... Scoring system: ... • Neutropenia, anemia ... leukemia #CLL
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... just beneath the skin ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... Syndromes #diagnosis #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Skin Lesion - Differential ... • Lymphoma • Leukemia ... Pruritus #secondary #systemic ... #generalized #dermatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... • Hypocellular myelodysplastic ... virus (EBV) • Leukemia ... #oncology #hematology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... the context of primary ... Seizures • Strokes Skin ... lymphopenia, low PLT • Anemia ... Hodgkin lymphoma and leukemia
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... of the immune system ... Types of HLH • Primary ... - Cytopenias (anemia ... #Hematology #HemeOnc
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