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diagnosis hematology differential leukemia mds syndrome anemia antinxp2 antinxp2dm aplastic chronic clinical common comparison cutaneous dermatomyositis distribution lymphocytic manifestations myelodysplasia
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... polymorphism • Satellite ... differential #diagnosis #dermatology ... #oncology #clinical ... #skin
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Allogeneic stem cell ... BrighamChiefs #Myelodysplastic ... #treatment #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
nontender cutaneous plaques ... ) CLL Symptoms: ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... : - CLL cells ... macules, papules, plaques ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic ... Myelodysplastic ... just beneath the skin ... Syndromes #diagnosis #hematology ... #oncology
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
scale • Basal cell ... on sun-damaged skin ... • Squamous cell ... macerated areas with satellite ... ; pruritis #dermatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
: - Indurated plaques ... large numbers of stellate ... Disease: - Lichen planus-like ... hematopoietic stem cell ... comparison #table #dermatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... • Hypocellular myelodysplastic ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... Violaceous papules or plaques ... ulcerations • Skin ... Dermatomyositis #diagnosis #management ... #rheumatology #dermatology
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