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diagnosis hematology differential leukemia antinxp2 antinxp2dm apml chronic comparison dermatomyositis differentiation distribution lymphocytic mds myelodysplasia myelodysplastic primarycare rash rheumatology scleroderma
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Hepatomegaly • Skin ... macules, papules, plaques ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... nontender cutaneous plaques ... • Tumor lysis syndrome ... -> Invade Skin: ... #Oncology #Diagnosis
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
Common Dermatological ... • Squamous cell ... macerated areas with satellite ... ; pruritis #dermatology ... #common #distribution
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
: - Indurated plaques ... large numbers of stellate ... - Occurs most commonly ... hematopoietic stem cell ... comparison #table #dermatology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
) is a skin condition ... Internal organs Most common ... general feeling of ill ... #diagnosis #dermatology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... just beneath the skin ... Most common cytopenia ... #diagnosis #hematology ... #oncology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... Violaceous papules or plaques ... renal carcinoma • Colon ... Dermatomyositis #diagnosis #management ... #rheumatology #dermatology
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