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diagnosis hematology differential leukemia rheumatology antinxp2 antinxp2dm apml chronic comparison dermatologic dermatomyositis differentiation distribution gpa granulomatosis lymphocytic mds myelodysplasia myelodysplastic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Hepatomegaly • Skin ... macules, papules, plaques ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... nontender cutaneous plaques ... • Tumor lysis syndrome ... -> Invade Skin: ... #Oncology #Diagnosis
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
Common Dermatological ... macerated areas with satellite ... ; pruritis #dermatology ... #rash #differential ... #common #distribution
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
polyangiitis (GPA) is common ... disease or more commonly ... Maculopapular rash ... • Goodpasture syndrome ... #rash #diagnosis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
sudden onset of a rash ... - Rash: multiple ... Internal organs Most common ... #diagnosis #dermatology ... #oncology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
: - Indurated plaques ... large numbers of stellate ... - Occurs most commonly ... hematopoietic stem cell ... comparison #table #dermatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... just beneath the skin ... Most common cytopenia ... #diagnosis #hematology ... #oncology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
(blue-purple) rash ... • Erythematous rash ... Violaceous papules or plaques ... Dermatomyositis #diagnosis #management ... #rheumatology #dermatology
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