12 results
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Novel (or Direct) Oral ... Rivaroxaban • Apixaban ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
, Rivaroxaban, Apixaban ... , Edoxaban, Betrixaban ... , DOAC, Parenteral ... anticoagulation #Switching #hematology ... #pharmacology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
(Praxbind) - Apixaban ... Betrixaban (Bevyxxa), Edoxaban ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... Anticoagulation #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents

Warfarin - 100% Hepatic, 0% Renal
Apixaban
Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... Hepatic, 35% Renal #DOAC ... #NOAC #Metabolism ... #Pharmacology #
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... not available #DOAC ... #Reversal #NOAC ... #hematology #management ... #pharmacology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... @Bloodman #DOAC ... Anticoagulation #Hematology ... #Pharmacology # ... #NOAC
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
(DOAC interactions ... , and apixaban are ... content/133/4/291 #DOAC ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
Currently, edoxaban ... direct-acting oral ... filtration rate; DOAC ... #DOAC #VTE #Malignancy ... Anticoagulation #Management #Hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
Effect of Direct Oral ... and edoxaban. ... thrombin time #doac ... #noac #anticoagulation ... #hematology #laboratory