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hematology management doac oncology anticoagulant anticoagulation apml blood chemotherapy cryofibrinogenemia cyp3a4 differentiation hemeonc heparin hit inducers inhibitors interactions mds myelodysplasia
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Anticoagulants Common Reversal ... (Praxbind) - Apixaban ... anticoagulation #doac ... #noac #pharmacology ... #hematology #reversal
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... Antidotes: • Apixaban ... #Reversal #NOAC ... anticoagulant #hematology ... #management #pharmacology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
(DOAC interactions ... rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Heparin Induced ... arterial thrombosis, skin ... including flushes), reverse ... , Bivalirudin, DOAC ... Management #Treatment #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
endothelial damage • Induce ... sepsis), PE, DAH, CHF ... overload, PCC to reverse ... Noah Rosenberg @ ... #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Diagnosis ... syndrome • Warfarin-induced ... Cryofibrinogenemia #diagnosis ... #rheumatology # ... hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
: • Leukocyte reduced ... patients with CHF ... infections with skin ... #Transfusions #diagnosis ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... unclassifiable: Reduced ... factors (examples: G-CSF ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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