15 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Anticoagulation #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban ... #Loading #DVT #Pharmacology ... #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Anti-Coagulants • Rivaroxaban ... • Apixaban ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
VKA, Dabigatran, Rivaroxaban ... , Apixaban, Edoxaban ... anticoagulation #Switching #hematology ... #pharmacology
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
(Praxbind) - Apixaban ... Edoxaban (Lixiana), Rivaroxaban ... anticoagulation #doac #noac #pharmacology ... #hematology #reversal
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Renal Dosing: Apixaban ... 60kg, CrCl 15-50 Rivaroxaban ... Anticoagulation #Hematology ... #Pharmacology # ... Apixaban #Rivaroxaban
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
Edoxaban, rivaroxaban ... , and apixaban are ... Rivaroxaban and ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Antidotes: • Apixaban ... , Edoxaban or Rivaroxaban ... anticoagulant #hematology ... #management #pharmacology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
diagnosis #models #hematology ... thrombin #inhibitor #Apixaban ... #Rivaroxaban #Edoxaban
Quick Guide to Reversing Antiplatelet and Antithrombotic Therapy
Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Abciximab, Tirofiban, Eptifibatide, Unfractionated Heparin,
Bivalirudin, Dabigatran, Apixaban ... Betrixaban, Edoxaban, Rivaroxaban ... anticoagulation #agents #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Xa inhibitors - Rivaroxaban ... , apixaban, edoxaban ... #differential #hematology