11 results
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
Common Reversal Agents ... Protamine sulfate - Dabigatran ... (Praxbind) - Apixaban ... anticoagulation #doac #noac #pharmacology ... #hematology #reversal
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Anticoagulation #Dabigatran ... #Apixaban #Rivaroxaban ... #Loading #DVT #Pharmacology ... #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet
Novel (or Direct) Oral Anti-Coagulants
 • Rivaroxaban
 • Apixaban
NOAC / DOAC Pharmacology ... Rivaroxaban • Apixaban ... • Dabigatran ... #NOAC #DOAC #Pharmacology ... #Prescribing #hematology
Switching Between Anticoagulants and DOACs
VKA, Dabigatran, Rivaroxaban, Apixaban, Edoxaban, Betrixaban, DOAC, Parenteral anticoagulant

DOI: 10.1161/JAHA.120.017559

#Anticoagulants #DOACs #anticoagulation
and DOACs VKA, Dabigatran ... , Rivaroxaban, Apixaban ... anticoagulation #Switching #hematology ... #pharmacology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
Renal Dosing: Apixaban ... recommend alternative agent ... Anticoagulation #Hematology ... #Pharmacology # ... Apixaban #Rivaroxaban
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
Rivaroxaban and apixaban ... Dabigatran has moderate ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Quick Guide to Reversing Antiplatelet and Antithrombotic Therapy
Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Abciximab, Tirofiban, Eptifibatide, Unfractionated Heparin,
, Bivalirudin, Dabigatran ... , Apixaban, Betrixaban ... anticoagulation #agents ... #hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
Antidotes: • Apixaban ... modified factor Xa • Dabigatran ... anticoagulant #hematology ... #management #pharmacology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Headaches • Pale skin ... salts • Chemical Agents ... Benzene • Physical Agents ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
• Exposure to Agent ... Hepatomegaly • Skin ... diagnosis #workup #oncology ... #hematology