10 results
diagnosis hematology differential monoclonal clinical leukemia myelodysplastic anemia aplastic chemotherapy chronic cll cutaneous cyp3a4 doac gammopathies gammopathy gap globulin inducers
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
most frequent skin ... polymorphism • Satellite ... differential #diagnosis #dermatology ... #oncology #clinical ... #skin
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... capillary leak syndrome ... • Schnitzler syndrome ... Differential #Diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MGCS • MGRS ... Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... Constitutional Syndromes ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... just beneath the skin ... #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Gammopathy Include: • MGUS ... gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
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